Biomedical Technology Resources
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Mass Spectrometry Resource for Biology and Medicine

Catherine E. Costello, Ph.D.

Center Overview

The resource's mission is to conduct high-sensitivity structural determinations and analyses of biological compounds via mass spectrometry (MS). The emphasis is on glycoconjugates, oligosaccharides, and proteins; structure-activity studies related to immunology, carcinogenesis, developmental biology, parasitology, and infectious diseases; biophysical properties of carbohydrates and glycoconjugates; carbohydrate and amino acid sequence determinations of glycoproteins and proteins; and structure elucidation of unusual residues and posttranslational modifications.

Current Research

Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) methods for high-sensitivity structural determinations. Chromatographic and electrophoretic methods for analysis of complex mixtures. Derivatization and degradation protocols (low/sub pmol) with an emphasis on maximizing the MS structural information. Ion chemistry studies to improve sensitivity and elucidate fragmentation patterns of native and derivatized biopolymers. MALDI methods for surface analysis. Fourier transform ion cyclotron resonance (FT-ICR) MS in biological studies. Atomic force microscopy to complement MS studies.