Biomedical Technology Resources
Collaboration Through Dissemination
Visit Website Back

National Center for Biomedical Glycomics (NCBG)

Michael Pierce, Ph.D.
P41RR018502
Active

Center Overview

The Integrated Technology Resource for Biomedical Glycomics was established in 2004 with funding from the National Center for Research Resources to develop and implement new technologies to investigate the Glycome of cells and exploit the use of these technologies to develop embryonic stem cell markers during their differentiation.

A critical component of the Resource Center is its Analytical Service and Training Core. During 2006, for example, this Core analyzed over 1000 samples for investigators from across the U.S. and the world, from both academia and industry. In addition, as Glycomics becomes recognized as a fundamental element of biomedical research, pharmaceutical and biotechnology companies, as well as diverse academic laboratories send students for our summer workshops, such as the Mass Spectrometry of Glycans and Glycoconjugates. More information regarding our Service and Training is available by clicking on the buttons in the navigation bar.

The technology development of the Resource is divided into several Cores: Stem Cell Platform, Glycoproteomics & Glycoconjugate Analysis, Transcript Analysis, and Bioinformatics. Use the navigation bar to get more information regarding these research areas.

The tools and technologies developed by the Resource Center are being applied to identifying markers for stem cells. As protocols are developed to cause differentiation of these cells into specific developmental lineages and cell types, the identification of developmental stage-specific markers is critical for separation of target cell populations. Since all cells are "sugar-coated", glycans are logical candidates for specific cell markers. Moreover, these technologies can be applied directly to identify diseased cell populations; for example, invasive breast carcinoma cells. Glycomic analyses are, therefore, of increasing interest to the biotechnology and pharmaceutical industries.

Impact on Human Health

Glycans expressed on proteins and lipids clearly regulate many physiological functions and are altered in diseases and disorders. Moreover, glycan expression changes in defined ways during embryonic development. The major focus of the Glycomics Resource is to develop tools and technologies to understand the glycomics of cells using the platform of stem cell differentiation. A product of the application of these technologies is the identification of cell surface markers that are specific for particular differentiated cell types. Many of our collaborative projects have utilized these tools for project that range from defining the ligand for laminin-alpha-dystroglycan binding to glycotranscript changes during oncogenesis.

Resources

ResourceDescriptionSupported PlatformsSupported FormatsData TypeData Size (compressed)
GlycomicsPortal
National Center for Biomedical Glycomics (NCBG)
NIGMS

GlycomicsPortal is a web based registry for glyco-bioinformatics tools (e.g. software, databases, ontologies, web services, workflows).

Web-Based N/A N/A
OntologyWebApi
National Center for Biomedical Glycomics (NCBG)
NIGMS

The OntologyWebApi is a set of web services allowing programmatic access to knowledge stored in NCBG ontologies (e.g. GlycO, ReferO)

Web-Based N/A N/A
Qrator
National Center for Biomedical Glycomics (NCBG)
NIGMS

Qrator is a web based application for the human curation of carbohydrate structures (glycans).

Web-Based N/A N/A
SimianTools
National Center for Biomedical Glycomics (NCBG)
NIGMS

SimianTools is a stand alone application for the postprocessing of glycomics mass spectrometric data annotated with the commercial program SimGlycan.

Windows N/A N/A
GlycO
National Center for Biomedical Glycomics (NCBG)
NIGMS

Glycomics Ontology, is an ontology focusing on the representation and storage of glycan structures and other molecules.

Ontology 0 - 500MB
ReferO
National Center for Biomedical Glycomics (NCBG)
NIGMS

Reference Ontology, is an ontology that complements concepts stored in the GlycO ontology with references to external sources (e.g. other database, biological source, publications)

Ontology 0 - 500MB