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Center for Electron Paramagnetic Resonance Imaging in Vivo Physiology

Howard Halpern, Ph.D. (Department of Radiation and Cellular Oncolog, MC1105, University of Chicago Medical Center, 5841 S Maryland Ave. Chicago, IL 60637 USA)
P41EB002034
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Center Overview

The major aim of this resource is the development of instrumentation, including novel resonant structures , analysis techniques, spin probes, and methodologies for imaging physiologically relevant aspects of tissue fluids, including high-resolution quantitative molecular oxygen (pO2) images, with very low frequency electron paramagnetic resonance imaging (EPRI). Novel bridges and high-access, magnet/gradient systems have produced physiologically relevant images of the oxygen dependence of the response of malignant tumors to conventional therapy (radiation) and the interaction between molecular biologic characteristics of tumor cells and their oxygenation environment. The resource is a consortium among the University of Chicago, the University of Denver, the University of Illinois, Urbana-Champagne, and the Novosibirsk Insititue of Organic Chemistry, Novosibirsk RU.

Tags

Elecctron Paramagnetic Resonance Imaging, Image Registration, Molecular O2 Imaging, Quantitative Physiologic Imaging