Biomedical Technology Resources
Collaboration Through Dissemination

Centers

P41 Centers with NIGMS

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Emory National Center for Functional Glycomics The "National Center for Functional Glycomics" (NCFG) as a Biomedical Technology Research Center (BTRC) is devoted to the technology of glycan recognition through microarray display and other modes of glycan presentation. This Center is the first of its kind with the central focus being exploration of the functional glycome of cells through technologies to define glycan recognition by glycan-binding proteins (GBPs). There is tremendous synergy between our research/technology development and the unmet needs of the ... more
Mass Spectrometry Resource for Biology and Medicine The resource's mission is to conduct high-sensitivity structural determinations and analyses of biological compounds via mass spectrometry (MS). The emphasis is on glycoconjugates, oligosaccharides, and proteins; structure-activity studies related to immunology, carcinogenesis, developmental biology, parasitology, and infectious diseases; biophysical properties of carbohydrates and glycoconjugates; carbohydrate and amino acid sequence determinations of glycoproteins and proteins; and structure elucidation of unusual residues and posttranslational modifications. Current Research Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) methods ... more
National Center for Biomedical Glycomics (NCBG) The Integrated Technology Resource for Biomedical Glycomics was established in 2004 with funding from the National Center for Research Resources to develop and implement new technologies to investigate the Glycome of cells and exploit the use of these technologies to develop embryonic stem cell markers during their differentiation. A critical component of the Resource Center is its Analytical Service and Training Core. During 2006, for example, this Core analyzed over 1000 samples for investigators from ... more
Resource for Integrated Glycotechnology The central goal of the Research Resource for Integrated Glycotechnology is to increase understanding of the molecular basis of protein-carbohydrate interactions in disease and to develop more powerful technologies necessary to achieve this understanding. The carbohydrates (glycans) found on cell surfaces and circulating as parts of soluble glycoproteins play a role in many biomedically important processes, including inflammatory response, hormone action, malignancy, viral and bacterial infections and cell differentiation. Over the past few years the ... more
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Center for Computational Mass-Spectrometry Center for Computational Mass Spectrometry (CCMS) is a national and international resource in the area of proteomics aimed at branching into previously unexplored areas of computational proteomics and supporting multiple collaborative efforts. The Center focuses on the computational bottlenecks that affects the entire proteomics community and impair interpretation of data in thousands of experimental labs. The goal of CCMS is to bring the modern algorithmic approaches to mass-spectrometry and to build a new generation of ... more
Center for Integrative Biomedical Computing (CIBC) The Center for Integrative Biomedical Computing is dedicated to producing opensource software tools for biomedical image-based modeling, biomedical simulation and estimation, and the visualization of biomedical data. The Center works closely with software users and collaborators in a range of scientific domains to produce user-optimized tools and provides advice, technical support, workshops, and education to enhance user success. Biological projects and collaborations drive our development efforts, all with a single unifying vision: to develop the ... more
Center for Macromolecular Modeling and Bioinformatics The Center for Macromolecular Modeling and Bioinformatics brings the most advanced molecular modeling and simulation, bioinformatics, and computational technologies to bear on questions of biomedical relevance. It extends, refines and delivers these technologies in response to experimental progress and emerging needs of the wide biomedical research community. The impact of the work is magnified through direct collaboration with experimental researchers, the distribution of cutting-edge and user-friendly software, and via extensive training, service, and dissemination efforts. ... more
National Biomedical Computation Resource The mission of the National Biomedical Computation Resource (NBCR) is to conduct, catalyze, and enable biomedical research by harnessing forefront computational and information technologies to solve multiscale analysis challenges in basic and translational science. During our seventeen years NBCR has successfully exploited and led new technology developments in computing to benefit the biomedical research community, and bridged the gap between emerging information technologies and NIH funded science across diverse biomedical research areas. Current efforts focus ... more
National Center for Biomedical Glycomics (NCBG) The Integrated Technology Resource for Biomedical Glycomics was established in 2004 with funding from the National Center for Research Resources to develop and implement new technologies to investigate the Glycome of cells and exploit the use of these technologies to develop embryonic stem cell markers during their differentiation. A critical component of the Resource Center is its Analytical Service and Training Core. During 2006, for example, this Core analyzed over 1000 samples for investigators from ... more
National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Center for Microscopy and Imaging Research The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer-aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, a range encompassing macromolecules, subcellular structures and cells. With novel specimen staining methods, imaging instruments and computational capabilities, researchers are addressing the next great biological challenges in the post-genomic age by situating proteins and macromolecular complexes in their cellular and tissue environments. ... more
National Center for Multiscale Modeling of Biological Systems (MMBioS) The National Center for Multiscale Modeling of Biological Systems (MMBioS) will develop tools to advance and facilitate cutting-edge research at the interface between high performance computing technology and the life sciences. Our overarching biological goal is the predictive multi-scale modeling of the spatiotemporal organization and evolution of neurosignaling systems and events. The advances made here will impact the research activities of a broad group of scientists, from molecular and structural biologists to cell and systems ... more
National Resource for Automated Molecular Microscopy The National Resource for Automated Molecular Microscopy (NRAMM) was established in 2003 with the mission of developing, testing and applying technology aimed at automating the processes involved in solving macromolecular structures using cryo-electron microscopy (cryoEM). The last decade has witnessed several dramatic milestones in the progress of Molecular Microscopy, a set of techniques and approaches used to analyze the structure of macromolecular machines using transmission electron microscopy (TEM). In 2008, maps of single macromolecules were ... more
National Resource for Cell Analysis and Modeling The National Resource for Cell Analysis and Modeling (NRCAM) develops new technologies for modeling cell biological processes. The technologies are integrated through Virtual Cell (VCell), a problem solving environment built on a central database and disseminated as a web application for analysis, modeling and simulation of cell biological processes. NRCAM has as its mission the growth of the VCell technology via research at the interface of physics, mathematics, computer science and biology. NRCAM is housed ... more
National Resource for Mass Spectrometric Analysis of Biological macromolecules The National Resource for Mass Spectrometric Analysis of Biological Macromolecules develops proteomic tools for dissecting cellular function, with a special emphasis on the mass spectrometry (MS) of peptides and proteins. And we apply these tools to the study of challenging biological problems. Impact on Human Health An aim of the lab is to develop new methods to study viral-host and viral-viral protein interactions during the progression of the highly dynamic viral infection. In particular, members ... more
National Resource for Network Biology Analysis of biological networks has exploded in recent years. A wide variety of technologies have become available for mapping biological networks at multiple levels and scales, from protein-protein and genetic interactions, to cell-cell communication, to vast social networks. The aim of the National Resource for Network Biology is to develop new algorithms, visualizations, and conceptual frameworks to integrate, query, and interpret these network data. Our technologies are enabling researchers to assemble models of networks and ... more
National Resource for Translational and Developmental Proteomics The science drivers for the National Resouce for Translational and Developmental Proteomics (NRTDP) are outlined in eight Driving Biomedical Projects that motivate the specific aims for four Technology Research and Development Projects. The impact of these combined activities, devoted to improving mass spectrometry-based proteomics using whole proteins as the primary unit of measurement, will be substantial. Integrated over all aspects of the resource (including biomedical application, technology development, dissemination and training), the projected impacts are aligned with both the spirit ... more
Proteomics Research Resource for Integrative Biology The Proteomics Research Resource for Integrative Biology at Pacific Northwest National Laboratory (PNNL) was established to provide new proteomic technologies for use in the biomedical research community. The possible roles and importance of proteomics are rapidly growing across essentially all areas of biological research. The precise and comprehensive measurement of levels of expressed proteins and their modified forms can provide new insights into the molecular nature of cell-signaling pathways and networks, the cell cycle, cellular ... more
Resource for Biocomputing, Visualization, and Informatics The Resource for Biocomputing, Visualization, and Informatics (RBVI) develops software and Web-based resources for the visualization and analysis of molecular structures and related data. Given the ever-expanding and increasingly heterogeneous universe of information on biological molecules - structural data at scales ranging from atomic to supramolecular, sequences, expression data, physical and genetic interactions, functional roles, associations with disease - researchers require truly integrative software to promote understanding of the data as a coherent whole. The ... more
Resource for Integrated Glycotechnology The central goal of the Research Resource for Integrated Glycotechnology is to increase understanding of the molecular basis of protein-carbohydrate interactions in disease and to develop more powerful technologies necessary to achieve this understanding. The carbohydrates (glycans) found on cell surfaces and circulating as parts of soluble glycoproteins play a role in many biomedically important processes, including inflammatory response, hormone action, malignancy, viral and bacterial infections and cell differentiation. Over the past few years the ... more
Yeast Resource Center The Yeast Resource Center (YRC) is a NCRR and NIGMS Biomedical Technology Research Center based at the University of Washington in Seattle, Washington. The YRC's mission is to (1) exploit the budding yeast Saccharomyces cerevisiae to develop novel technologies for investigating and characterizing protein function and protein structure (2) facilitate research and extension of new technologies through collaboration, and (3) actively disseminate data and technology to the research community. Through collaboration, the YRC freely provides ... more
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National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Center for Microscopy and Imaging Research The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer-aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, a range encompassing macromolecules, subcellular structures and cells. With novel specimen staining methods, imaging instruments and computational capabilities, researchers are addressing the next great biological challenges in the post-genomic age by situating proteins and macromolecular complexes in their cellular and tissue environments. ... more
National Center for X-Ray Tomography The National Center for X-ray Tomography develops novel cellular imaging technologies for biological and biomedical research. In particular, the NCXT is developing soft x-ray tomography as a new tool for visualizing and quantifying the internal structure of whole, hydrated cells, and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules. Data from these two imaging modalities can be combined to form a single, correlated imaging view of a cell. This work is ... more
The Boulder Laboratory for 3-D Electron Microscopy of Cells The Boulder laboratory for 3-D electron microscopy of cells has functioned as a NCRR funded research resource since 1970. The lab has been successful in developing methods for imaging diverse cells and tissues in three dimensions (3-D) at a resolution of ~ 5 nm. The numerous features of cell structure that become visible at this level are highly informative about the mechanisms that underlie cellular processes. The overall strategy of the current research in the ... more
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National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Resource for Automated Molecular Microscopy The National Resource for Automated Molecular Microscopy (NRAMM) was established in 2003 with the mission of developing, testing and applying technology aimed at automating the processes involved in solving macromolecular structures using cryo-electron microscopy (cryoEM). The last decade has witnessed several dramatic milestones in the progress of Molecular Microscopy, a set of techniques and approaches used to analyze the structure of macromolecular machines using transmission electron microscopy (TEM). In 2008, maps of single macromolecules were ... more
The Boulder Laboratory for 3-D Electron Microscopy of Cells The Boulder laboratory for 3-D electron microscopy of cells has functioned as a NCRR funded research resource since 1970. The lab has been successful in developing methods for imaging diverse cells and tissues in three dimensions (3-D) at a resolution of ~ 5 nm. The numerous features of cell structure that become visible at this level are highly informative about the mechanisms that underlie cellular processes. The overall strategy of the current research in the ... more
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Center for Computational Mass-Spectrometry Center for Computational Mass Spectrometry (CCMS) is a national and international resource in the area of proteomics aimed at branching into previously unexplored areas of computational proteomics and supporting multiple collaborative efforts. The Center focuses on the computational bottlenecks that affects the entire proteomics community and impair interpretation of data in thousands of experimental labs. The goal of CCMS is to bring the modern algorithmic approaches to mass-spectrometry and to build a new generation of ... more
Center for Integrative Biomedical Computing (CIBC) The Center for Integrative Biomedical Computing is dedicated to producing opensource software tools for biomedical image-based modeling, biomedical simulation and estimation, and the visualization of biomedical data. The Center works closely with software users and collaborators in a range of scientific domains to produce user-optimized tools and provides advice, technical support, workshops, and education to enhance user success. Biological projects and collaborations drive our development efforts, all with a single unifying vision: to develop the ... more
Center for Macromolecular Modeling and Bioinformatics The Center for Macromolecular Modeling and Bioinformatics brings the most advanced molecular modeling and simulation, bioinformatics, and computational technologies to bear on questions of biomedical relevance. It extends, refines and delivers these technologies in response to experimental progress and emerging needs of the wide biomedical research community. The impact of the work is magnified through direct collaboration with experimental researchers, the distribution of cutting-edge and user-friendly software, and via extensive training, service, and dissemination efforts. ... more
National Biomedical Computation Resource The mission of the National Biomedical Computation Resource (NBCR) is to conduct, catalyze, and enable biomedical research by harnessing forefront computational and information technologies to solve multiscale analysis challenges in basic and translational science. During our seventeen years NBCR has successfully exploited and led new technology developments in computing to benefit the biomedical research community, and bridged the gap between emerging information technologies and NIH funded science across diverse biomedical research areas. Current efforts focus ... more
National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Center for Microscopy and Imaging Research The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer-aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, a range encompassing macromolecules, subcellular structures and cells. With novel specimen staining methods, imaging instruments and computational capabilities, researchers are addressing the next great biological challenges in the post-genomic age by situating proteins and macromolecular complexes in their cellular and tissue environments. ... more
National Center for Multiscale Modeling of Biological Systems (MMBioS) The National Center for Multiscale Modeling of Biological Systems (MMBioS) will develop tools to advance and facilitate cutting-edge research at the interface between high performance computing technology and the life sciences. Our overarching biological goal is the predictive multi-scale modeling of the spatiotemporal organization and evolution of neurosignaling systems and events. The advances made here will impact the research activities of a broad group of scientists, from molecular and structural biologists to cell and systems ... more
National Resource for Automated Molecular Microscopy The National Resource for Automated Molecular Microscopy (NRAMM) was established in 2003 with the mission of developing, testing and applying technology aimed at automating the processes involved in solving macromolecular structures using cryo-electron microscopy (cryoEM). The last decade has witnessed several dramatic milestones in the progress of Molecular Microscopy, a set of techniques and approaches used to analyze the structure of macromolecular machines using transmission electron microscopy (TEM). In 2008, maps of single macromolecules were ... more
National Resource for Cell Analysis and Modeling The National Resource for Cell Analysis and Modeling (NRCAM) develops new technologies for modeling cell biological processes. The technologies are integrated through Virtual Cell (VCell), a problem solving environment built on a central database and disseminated as a web application for analysis, modeling and simulation of cell biological processes. NRCAM has as its mission the growth of the VCell technology via research at the interface of physics, mathematics, computer science and biology. NRCAM is housed ... more
National Resource for Network Biology Analysis of biological networks has exploded in recent years. A wide variety of technologies have become available for mapping biological networks at multiple levels and scales, from protein-protein and genetic interactions, to cell-cell communication, to vast social networks. The aim of the National Resource for Network Biology is to develop new algorithms, visualizations, and conceptual frameworks to integrate, query, and interpret these network data. Our technologies are enabling researchers to assemble models of networks and ... more
Resource for Biocomputing, Visualization, and Informatics The Resource for Biocomputing, Visualization, and Informatics (RBVI) develops software and Web-based resources for the visualization and analysis of molecular structures and related data. Given the ever-expanding and increasingly heterogeneous universe of information on biological molecules - structural data at scales ranging from atomic to supramolecular, sequences, expression data, physical and genetic interactions, functional roles, associations with disease - researchers require truly integrative software to promote understanding of the data as a coherent whole. The ... more
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National Center for Microscopy and Imaging Research The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer-aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, a range encompassing macromolecules, subcellular structures and cells. With novel specimen staining methods, imaging instruments and computational capabilities, researchers are addressing the next great biological challenges in the post-genomic age by situating proteins and macromolecular complexes in their cellular and tissue environments. ... more
The Boulder Laboratory for 3-D Electron Microscopy of Cells The Boulder laboratory for 3-D electron microscopy of cells has functioned as a NCRR funded research resource since 1970. The lab has been successful in developing methods for imaging diverse cells and tissues in three dimensions (3-D) at a resolution of ~ 5 nm. The numerous features of cell structure that become visible at this level are highly informative about the mechanisms that underlie cellular processes. The overall strategy of the current research in the ... more
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Biophysics Collaborative Access Team The Biophysics Collaborative Access Team (BioCAT) operates undulator beamline 18ID at the Advanced Photon Source, Argonne National Laboratory. BioCAT's mission is to provide a national research resource for using X-ray diffraction, scattering and spectroscopic imaging technologies for the study of partially ordered biological molecules, complexes of biomolecules, and cellular structures under conditions similar to those present in living cells and tissues. The goal of this research is to understand the detailed mechanisms of action of ... more
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Emory National Center for Functional Glycomics The "National Center for Functional Glycomics" (NCFG) as a Biomedical Technology Research Center (BTRC) is devoted to the technology of glycan recognition through microarray display and other modes of glycan presentation. This Center is the first of its kind with the central focus being exploration of the functional glycome of cells through technologies to define glycan recognition by glycan-binding proteins (GBPs). There is tremendous synergy between our research/technology development and the unmet needs of the ... more
Mass Spectrometry Resource for Biology and Medicine The resource's mission is to conduct high-sensitivity structural determinations and analyses of biological compounds via mass spectrometry (MS). The emphasis is on glycoconjugates, oligosaccharides, and proteins; structure-activity studies related to immunology, carcinogenesis, developmental biology, parasitology, and infectious diseases; biophysical properties of carbohydrates and glycoconjugates; carbohydrate and amino acid sequence determinations of glycoproteins and proteins; and structure elucidation of unusual residues and posttranslational modifications. Current Research Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) methods ... more
National Center for Biomedical Glycomics (NCBG) The Integrated Technology Resource for Biomedical Glycomics was established in 2004 with funding from the National Center for Research Resources to develop and implement new technologies to investigate the Glycome of cells and exploit the use of these technologies to develop embryonic stem cell markers during their differentiation. A critical component of the Resource Center is its Analytical Service and Training Core. During 2006, for example, this Core analyzed over 1000 samples for investigators from ... more
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Biophysics Collaborative Access Team The Biophysics Collaborative Access Team (BioCAT) operates undulator beamline 18ID at the Advanced Photon Source, Argonne National Laboratory. BioCAT's mission is to provide a national research resource for using X-ray diffraction, scattering and spectroscopic imaging technologies for the study of partially ordered biological molecules, complexes of biomolecules, and cellular structures under conditions similar to those present in living cells and tissues. The goal of this research is to understand the detailed mechanisms of action of ... more
National Center for Microscopy and Imaging Research The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer-aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, a range encompassing macromolecules, subcellular structures and cells. With novel specimen staining methods, imaging instruments and computational capabilities, researchers are addressing the next great biological challenges in the post-genomic age by situating proteins and macromolecular complexes in their cellular and tissue environments. ... more
National Center for X-Ray Tomography The National Center for X-ray Tomography develops novel cellular imaging technologies for biological and biomedical research. In particular, the NCXT is developing soft x-ray tomography as a new tool for visualizing and quantifying the internal structure of whole, hydrated cells, and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules. Data from these two imaging modalities can be combined to form a single, correlated imaging view of a cell. This work is ... more
National Research Resource for Imaging Mass Spectrometry The National Research Resource for Imaging Mass Spectrometry was founded at the Vanderbilt University Mass Spectrometry Research Center in 2011. The mission of this National Research Resource is to advance the technology of Imaging Mass Spectrometry (IMS), to facilitate the application of this novel imaging modality to problems of biological and clinical significance, and to promote the adoption of these technologies by a larger community of scientists and clinicians. In order to fulfill this mission, ... more
The Boulder Laboratory for 3-D Electron Microscopy of Cells The Boulder laboratory for 3-D electron microscopy of cells has functioned as a NCRR funded research resource since 1970. The lab has been successful in developing methods for imaging diverse cells and tissues in three dimensions (3-D) at a resolution of ~ 5 nm. The numerous features of cell structure that become visible at this level are highly informative about the mechanisms that underlie cellular processes. The overall strategy of the current research in the ... more
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BioCARS: A Synchrotron Structural Biology Resource BioCARS is a national user facility for synchrotron-based static and dynamic studies of biological macromolecules, located at the Advanced Photon Source, Argonne National Laboratory. The mission of BioCARS is to develop state-of-the art facilities and provide scientific and technical expertise and user support for studies of dynamic (and static) properties of macromolecules by X-ray scattering techniques such as crystallography, SAXS/WAXS and fiber diffraction. BioCARS operates two X-ray beamlines, embedded in a Biosafety Level 3 (BSL-3) ... more
Life Science and Biomedical Technology Research Resource The project will develop a world-leading suite of experimental facilities for the life-science research community. With the focus on macromolecular crystallography (MX) and x-ray scattering, there will also be user programs in correlated MX and optical spectroscopy, and one in fluorescence imaging of metals in biological materials. The extraordinary brightness of NSLS-II will provide unprecedentedly small, bright, and well-collimated x-ray beams. To exploit these qualities, extra care will be exerted to provide the best quality ... more
Macromolecular Diffraction at CHESS (MacCHESS) To understand how macromolecules such as proteins and DNA work, we need to know their structure. The "gold standard" for determining macromolecular structures at the atomic level is x-ray crystallography, and the premier source of x-rays is synchrotron radiation from a storage ring. The MacCHESS Research Resource supports structural biologists who use the Cornell High Energy Synchrotron Source (CHESS) to determine crystal structures of a broad range of biomedically relevant proteins and macromolecular complexes. MacCHESS ... more
NE-CAT Center for Macromolecular Crystallography The NE-CAT Center for Macromolecular Crystallography is a facility that uses high intensity X-rays to determine the three-dimensional arrangement of atoms in biological molecules. The Resource is located at Sector 24 of the Advanced Photon Source (APS) at Argonne National Laboratory (ANL), and overseen by the Northeastern Collaborative Access Team, which includes scientists from across the country. Determining the composition of molecules and visualizing their interactions at the molecular level provides insights into how cells transmit signals, ... more
Synchrotron Radiation Structural Biology Resource The SSRL Structural Molecular Biology (SMB) program operates as an integrated resource and has three primary areas (or cores) of technological research and development and scientific focus: macromolecular crystallography (MC), x-ray absorption spectroscopy (XAS), and small angle x-ray scattering/diffraction (SAXS).Central to the core technological developments in all three of these areas is the development and utilization of improved detectors and instrumentation, especially to be able to take maximum advantage of the increasingly high brightness of ... more
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Bio-Organic Biomedical Mass Spectrometry Resource The National Bio-Organic, Biomedical Mass Spectrometry Resource Center, supported by the NIH National Center for Research Resources, provides both scientific and technical expertise in mass spectrometry and proteomics as well as the indispensible state-of-the-art high-performance, tandem mass spectrometric instrumentation. The facility is a world leader in proteomic analysis focused on addressing daunting challenges posed by poorly understood molecular-level underpinnings of human protein biology. In addition, it provides a service for small molecule analysis. Significant instrumentation ... more
Center for Computational Mass-Spectrometry Center for Computational Mass Spectrometry (CCMS) is a national and international resource in the area of proteomics aimed at branching into previously unexplored areas of computational proteomics and supporting multiple collaborative efforts. The Center focuses on the computational bottlenecks that affects the entire proteomics community and impair interpretation of data in thousands of experimental labs. The goal of CCMS is to bring the modern algorithmic approaches to mass-spectrometry and to build a new generation of ... more
Mass Spectrometry Resource for Biology and Medicine The resource's mission is to conduct high-sensitivity structural determinations and analyses of biological compounds via mass spectrometry (MS). The emphasis is on glycoconjugates, oligosaccharides, and proteins; structure-activity studies related to immunology, carcinogenesis, developmental biology, parasitology, and infectious diseases; biophysical properties of carbohydrates and glycoconjugates; carbohydrate and amino acid sequence determinations of glycoproteins and proteins; and structure elucidation of unusual residues and posttranslational modifications. Current Research Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) methods ... more
National Center for Biomedical Glycomics (NCBG) The Integrated Technology Resource for Biomedical Glycomics was established in 2004 with funding from the National Center for Research Resources to develop and implement new technologies to investigate the Glycome of cells and exploit the use of these technologies to develop embryonic stem cell markers during their differentiation. A critical component of the Resource Center is its Analytical Service and Training Core. During 2006, for example, this Core analyzed over 1000 samples for investigators from ... more
National Research Resource for Imaging Mass Spectrometry The National Research Resource for Imaging Mass Spectrometry was founded at the Vanderbilt University Mass Spectrometry Research Center in 2011. The mission of this National Research Resource is to advance the technology of Imaging Mass Spectrometry (IMS), to facilitate the application of this novel imaging modality to problems of biological and clinical significance, and to promote the adoption of these technologies by a larger community of scientists and clinicians. In order to fulfill this mission, ... more
National Resource for Biomedical Accelerator Mass Spectrometry Biomedical Accelerator Mass Spectrometry (AMS) is a U.S. National User Facility Research Resource, established and funded by the National Center for Research Resources (NCRR) at the National Institutes of Health (NIH). It is located within the Center for Accelerator Mass Spectrometry (CAMS) and the Physical and Life Sciences Directorate at the Department of Energy's Lawrence Livermore National Laboratory (LLNL). This national user facility has been established to make Accelerator Mass Spectrometry available to researchers who ... more
National Resource for Mass Spectrometric Analysis of Biological macromolecules The National Resource for Mass Spectrometric Analysis of Biological Macromolecules develops proteomic tools for dissecting cellular function, with a special emphasis on the mass spectrometry (MS) of peptides and proteins. And we apply these tools to the study of challenging biological problems. Impact on Human Health An aim of the lab is to develop new methods to study viral-host and viral-viral protein interactions during the progression of the highly dynamic viral infection. In particular, members ... more
National Resource for Translational and Developmental Proteomics The science drivers for the National Resouce for Translational and Developmental Proteomics (NRTDP) are outlined in eight Driving Biomedical Projects that motivate the specific aims for four Technology Research and Development Projects. The impact of these combined activities, devoted to improving mass spectrometry-based proteomics using whole proteins as the primary unit of measurement, will be substantial. Integrated over all aspects of the resource (including biomedical application, technology development, dissemination and training), the projected impacts are aligned with both the spirit ... more
Proteomics Research Resource for Integrative Biology The Proteomics Research Resource for Integrative Biology at Pacific Northwest National Laboratory (PNNL) was established to provide new proteomic technologies for use in the biomedical research community. The possible roles and importance of proteomics are rapidly growing across essentially all areas of biological research. The precise and comprehensive measurement of levels of expressed proteins and their modified forms can provide new insights into the molecular nature of cell-signaling pathways and networks, the cell cycle, cellular ... more
Resource for Biomedical and Bio-Organic Mass Spectrometry Mass spectrometry (MS) plays a vital role in biomedical research. In addition to its important traditional roles of structure determination of small molecules, trace analysis, and the identification of metabolites, carcinogens, and natural products, MS has become the premier tool for identification of proteins, lipids, carbohydrates, and short sequences of nucleic acids. It is the tool that enables the emerging "omics" sciences (e.g., proteomics, lipidomics, glycomics) that aim for a comprehensive understanding of human health ... more
Resource for Integrated Glycotechnology The central goal of the Research Resource for Integrated Glycotechnology is to increase understanding of the molecular basis of protein-carbohydrate interactions in disease and to develop more powerful technologies necessary to achieve this understanding. The carbohydrates (glycans) found on cell surfaces and circulating as parts of soluble glycoproteins play a role in many biomedically important processes, including inflammatory response, hormone action, malignancy, viral and bacterial infections and cell differentiation. Over the past few years the ... more
Yeast Resource Center The Yeast Resource Center (YRC) is a NCRR and NIGMS Biomedical Technology Research Center based at the University of Washington in Seattle, Washington. The YRC's mission is to (1) exploit the budding yeast Saccharomyces cerevisiae to develop novel technologies for investigating and characterizing protein function and protein structure (2) facilitate research and extension of new technologies through collaboration, and (3) actively disseminate data and technology to the research community. Through collaboration, the YRC freely provides ... more
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National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Center for Microscopy and Imaging Research The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer-aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, a range encompassing macromolecules, subcellular structures and cells. With novel specimen staining methods, imaging instruments and computational capabilities, researchers are addressing the next great biological challenges in the post-genomic age by situating proteins and macromolecular complexes in their cellular and tissue environments. ... more
National Center for X-Ray Tomography The National Center for X-ray Tomography develops novel cellular imaging technologies for biological and biomedical research. In particular, the NCXT is developing soft x-ray tomography as a new tool for visualizing and quantifying the internal structure of whole, hydrated cells, and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules. Data from these two imaging modalities can be combined to form a single, correlated imaging view of a cell. This work is ... more
National Resource for Automated Molecular Microscopy The National Resource for Automated Molecular Microscopy (NRAMM) was established in 2003 with the mission of developing, testing and applying technology aimed at automating the processes involved in solving macromolecular structures using cryo-electron microscopy (cryoEM). The last decade has witnessed several dramatic milestones in the progress of Molecular Microscopy, a set of techniques and approaches used to analyze the structure of macromolecular machines using transmission electron microscopy (TEM). In 2008, maps of single macromolecules were ... more
The Boulder Laboratory for 3-D Electron Microscopy of Cells The Boulder laboratory for 3-D electron microscopy of cells has functioned as a NCRR funded research resource since 1970. The lab has been successful in developing methods for imaging diverse cells and tissues in three dimensions (3-D) at a resolution of ~ 5 nm. The numerous features of cell structure that become visible at this level are highly informative about the mechanisms that underlie cellular processes. The overall strategy of the current research in the ... more
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Center for Integrative Biomedical Computing (CIBC) The Center for Integrative Biomedical Computing is dedicated to producing opensource software tools for biomedical image-based modeling, biomedical simulation and estimation, and the visualization of biomedical data. The Center works closely with software users and collaborators in a range of scientific domains to produce user-optimized tools and provides advice, technical support, workshops, and education to enhance user success. Biological projects and collaborations drive our development efforts, all with a single unifying vision: to develop the ... more
Center for Macromolecular Modeling and Bioinformatics The Center for Macromolecular Modeling and Bioinformatics brings the most advanced molecular modeling and simulation, bioinformatics, and computational technologies to bear on questions of biomedical relevance. It extends, refines and delivers these technologies in response to experimental progress and emerging needs of the wide biomedical research community. The impact of the work is magnified through direct collaboration with experimental researchers, the distribution of cutting-edge and user-friendly software, and via extensive training, service, and dissemination efforts. ... more
National Biomedical Computation Resource The mission of the National Biomedical Computation Resource (NBCR) is to conduct, catalyze, and enable biomedical research by harnessing forefront computational and information technologies to solve multiscale analysis challenges in basic and translational science. During our seventeen years NBCR has successfully exploited and led new technology developments in computing to benefit the biomedical research community, and bridged the gap between emerging information technologies and NIH funded science across diverse biomedical research areas. Current efforts focus ... more
National Center for Dynamic Interactome Research The emergent properties of life require the dynamic interactions of macromolecules, the two major classes of which are proteins and nucleic acids. These interactions form macromolecular machines and dynamic liaisons that shape the cell, transmit information and control cellular behaviors, and pathogenic alterations in molecular interaction networks (interactomes) underlie disease. Our understanding and modulation of biological systems, as well as their pathologies, thus relies on the ability to elucidate and interpret these interactions and their ... more
National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Center for Multiscale Modeling of Biological Systems (MMBioS) The National Center for Multiscale Modeling of Biological Systems (MMBioS) will develop tools to advance and facilitate cutting-edge research at the interface between high performance computing technology and the life sciences. Our overarching biological goal is the predictive multi-scale modeling of the spatiotemporal organization and evolution of neurosignaling systems and events. The advances made here will impact the research activities of a broad group of scientists, from molecular and structural biologists to cell and systems ... more
National Resource for Cell Analysis and Modeling The National Resource for Cell Analysis and Modeling (NRCAM) develops new technologies for modeling cell biological processes. The technologies are integrated through Virtual Cell (VCell), a problem solving environment built on a central database and disseminated as a web application for analysis, modeling and simulation of cell biological processes. NRCAM has as its mission the growth of the VCell technology via research at the interface of physics, mathematics, computer science and biology. NRCAM is housed ... more
National Resource for Network Biology Analysis of biological networks has exploded in recent years. A wide variety of technologies have become available for mapping biological networks at multiple levels and scales, from protein-protein and genetic interactions, to cell-cell communication, to vast social networks. The aim of the National Resource for Network Biology is to develop new algorithms, visualizations, and conceptual frameworks to integrate, query, and interpret these network data. Our technologies are enabling researchers to assemble models of networks and ... more
Resource for Biocomputing, Visualization, and Informatics The Resource for Biocomputing, Visualization, and Informatics (RBVI) develops software and Web-based resources for the visualization and analysis of molecular structures and related data. Given the ever-expanding and increasingly heterogeneous universe of information on biological molecules - structural data at scales ranging from atomic to supramolecular, sequences, expression data, physical and genetic interactions, functional roles, associations with disease - researchers require truly integrative software to promote understanding of the data as a coherent whole. The ... more
Resource for Integrated Glycotechnology The central goal of the Research Resource for Integrated Glycotechnology is to increase understanding of the molecular basis of protein-carbohydrate interactions in disease and to develop more powerful technologies necessary to achieve this understanding. The carbohydrates (glycans) found on cell surfaces and circulating as parts of soluble glycoproteins play a role in many biomedically important processes, including inflammatory response, hormone action, malignancy, viral and bacterial infections and cell differentiation. Over the past few years the ... more
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Bio-Organic Biomedical Mass Spectrometry Resource The National Bio-Organic, Biomedical Mass Spectrometry Resource Center, supported by the NIH National Center for Research Resources, provides both scientific and technical expertise in mass spectrometry and proteomics as well as the indispensible state-of-the-art high-performance, tandem mass spectrometric instrumentation. The facility is a world leader in proteomic analysis focused on addressing daunting challenges posed by poorly understood molecular-level underpinnings of human protein biology. In addition, it provides a service for small molecule analysis. Significant instrumentation ... more
Center for Computational Mass-Spectrometry Center for Computational Mass Spectrometry (CCMS) is a national and international resource in the area of proteomics aimed at branching into previously unexplored areas of computational proteomics and supporting multiple collaborative efforts. The Center focuses on the computational bottlenecks that affects the entire proteomics community and impair interpretation of data in thousands of experimental labs. The goal of CCMS is to bring the modern algorithmic approaches to mass-spectrometry and to build a new generation of ... more
Mass Spectrometry Resource for Biology and Medicine The resource's mission is to conduct high-sensitivity structural determinations and analyses of biological compounds via mass spectrometry (MS). The emphasis is on glycoconjugates, oligosaccharides, and proteins; structure-activity studies related to immunology, carcinogenesis, developmental biology, parasitology, and infectious diseases; biophysical properties of carbohydrates and glycoconjugates; carbohydrate and amino acid sequence determinations of glycoproteins and proteins; and structure elucidation of unusual residues and posttranslational modifications. Current Research Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) methods ... more
National Center for Dynamic Interactome Research The emergent properties of life require the dynamic interactions of macromolecules, the two major classes of which are proteins and nucleic acids. These interactions form macromolecular machines and dynamic liaisons that shape the cell, transmit information and control cellular behaviors, and pathogenic alterations in molecular interaction networks (interactomes) underlie disease. Our understanding and modulation of biological systems, as well as their pathologies, thus relies on the ability to elucidate and interpret these interactions and their ... more
National Resource for Mass Spectrometric Analysis of Biological macromolecules The National Resource for Mass Spectrometric Analysis of Biological Macromolecules develops proteomic tools for dissecting cellular function, with a special emphasis on the mass spectrometry (MS) of peptides and proteins. And we apply these tools to the study of challenging biological problems. Impact on Human Health An aim of the lab is to develop new methods to study viral-host and viral-viral protein interactions during the progression of the highly dynamic viral infection. In particular, members ... more
National Resource for Network Biology Analysis of biological networks has exploded in recent years. A wide variety of technologies have become available for mapping biological networks at multiple levels and scales, from protein-protein and genetic interactions, to cell-cell communication, to vast social networks. The aim of the National Resource for Network Biology is to develop new algorithms, visualizations, and conceptual frameworks to integrate, query, and interpret these network data. Our technologies are enabling researchers to assemble models of networks and ... more
National Resource for Translational and Developmental Proteomics The science drivers for the National Resouce for Translational and Developmental Proteomics (NRTDP) are outlined in eight Driving Biomedical Projects that motivate the specific aims for four Technology Research and Development Projects. The impact of these combined activities, devoted to improving mass spectrometry-based proteomics using whole proteins as the primary unit of measurement, will be substantial. Integrated over all aspects of the resource (including biomedical application, technology development, dissemination and training), the projected impacts are aligned with both the spirit ... more
Proteomics Research Resource for Integrative Biology The Proteomics Research Resource for Integrative Biology at Pacific Northwest National Laboratory (PNNL) was established to provide new proteomic technologies for use in the biomedical research community. The possible roles and importance of proteomics are rapidly growing across essentially all areas of biological research. The precise and comprehensive measurement of levels of expressed proteins and their modified forms can provide new insights into the molecular nature of cell-signaling pathways and networks, the cell cycle, cellular ... more
Resource for Biomedical and Bio-Organic Mass Spectrometry Mass spectrometry (MS) plays a vital role in biomedical research. In addition to its important traditional roles of structure determination of small molecules, trace analysis, and the identification of metabolites, carcinogens, and natural products, MS has become the premier tool for identification of proteins, lipids, carbohydrates, and short sequences of nucleic acids. It is the tool that enables the emerging "omics" sciences (e.g., proteomics, lipidomics, glycomics) that aim for a comprehensive understanding of human health ... more
Yeast Resource Center The Yeast Resource Center (YRC) is a NCRR and NIGMS Biomedical Technology Research Center based at the University of Washington in Seattle, Washington. The YRC's mission is to (1) exploit the budding yeast Saccharomyces cerevisiae to develop novel technologies for investigating and characterizing protein function and protein structure (2) facilitate research and extension of new technologies through collaboration, and (3) actively disseminate data and technology to the research community. Through collaboration, the YRC freely provides ... more
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Biophysics Collaborative Access Team The Biophysics Collaborative Access Team (BioCAT) operates undulator beamline 18ID at the Advanced Photon Source, Argonne National Laboratory. BioCAT's mission is to provide a national research resource for using X-ray diffraction, scattering and spectroscopic imaging technologies for the study of partially ordered biological molecules, complexes of biomolecules, and cellular structures under conditions similar to those present in living cells and tissues. The goal of this research is to understand the detailed mechanisms of action of ... more
Macromolecular Diffraction at CHESS (MacCHESS) To understand how macromolecules such as proteins and DNA work, we need to know their structure. The "gold standard" for determining macromolecular structures at the atomic level is x-ray crystallography, and the premier source of x-rays is synchrotron radiation from a storage ring. The MacCHESS Research Resource supports structural biologists who use the Cornell High Energy Synchrotron Source (CHESS) to determine crystal structures of a broad range of biomedically relevant proteins and macromolecular complexes. MacCHESS ... more
Synchrotron Radiation Structural Biology Resource The SSRL Structural Molecular Biology (SMB) program operates as an integrated resource and has three primary areas (or cores) of technological research and development and scientific focus: macromolecular crystallography (MC), x-ray absorption spectroscopy (XAS), and small angle x-ray scattering/diffraction (SAXS).Central to the core technological developments in all three of these areas is the development and utilization of improved detectors and instrumentation, especially to be able to take maximum advantage of the increasingly high brightness of ... more
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Laboratory for Fluorescence Dynamics The Laboratory for Fluorescence Dynamics (LFD is a national resource center dedicated to development of new fluorescence technologies for biology and medicine and service, training, and dissemination of fluorescence methods in a user facility. In previous years (1986-2010), we established our reputation as the leaders in technological development for fluorescence dynamics. Since moving to UCI in 2006, we expanded the core research and collaborative work in this new fertile biomedical research environment. Projects include: new ... more
National Biomedical Center for Advanced ESR Technology The National Biomedical Center for Advanced ESR Technology (ACERT) develops methods, both experimental and theoretical, of modern Electron-Spin Resonance (ESR) for biomedical applications. The technologies upon which this Center is based are in many respects unique in the world; and they are being utilized in numerous ways. One is the development of pulse-ESR methods to determine the structure of protein complexes, which are too large for crytallography or NMR, and yet provides information at an ... more
National Magnetic Resonance Facility at Madison The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource for biomolecular nuclear magnetic resonance (NMR) spectroscopy. NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high throughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, including complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and ... more
Synchrotron Radiation Structural Biology Resource The SSRL Structural Molecular Biology (SMB) program operates as an integrated resource and has three primary areas (or cores) of technological research and development and scientific focus: macromolecular crystallography (MC), x-ray absorption spectroscopy (XAS), and small angle x-ray scattering/diffraction (SAXS).Central to the core technological developments in all three of these areas is the development and utilization of improved detectors and instrumentation, especially to be able to take maximum advantage of the increasingly high brightness of ... more
Ultrafast Optical Processes Laboratory The Regional Laser and Biomedical Technology Laboratories (RLBL) at the University of Pennsylvania, specializes in the application of laser spectroscopy to biochemical, biophysical and biomedical research. The primary focus is on developing laser-based technologies to measure atomic level features of the fastest steps occurring in biological processes. This involves a balanced approach concerned with the design and implementation of laser systems, the incorporation of advances in laser technology into configurations suitable for biophysical research and ... more
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BioCARS: A Synchrotron Structural Biology Resource BioCARS is a national user facility for synchrotron-based static and dynamic studies of biological macromolecules, located at the Advanced Photon Source, Argonne National Laboratory. The mission of BioCARS is to develop state-of-the art facilities and provide scientific and technical expertise and user support for studies of dynamic (and static) properties of macromolecules by X-ray scattering techniques such as crystallography, SAXS/WAXS and fiber diffraction. BioCARS operates two X-ray beamlines, embedded in a Biosafety Level 3 (BSL-3) ... more
Biophysics Collaborative Access Team The Biophysics Collaborative Access Team (BioCAT) operates undulator beamline 18ID at the Advanced Photon Source, Argonne National Laboratory. BioCAT's mission is to provide a national research resource for using X-ray diffraction, scattering and spectroscopic imaging technologies for the study of partially ordered biological molecules, complexes of biomolecules, and cellular structures under conditions similar to those present in living cells and tissues. The goal of this research is to understand the detailed mechanisms of action of ... more
Center for Macromolecular Modeling and Bioinformatics The Center for Macromolecular Modeling and Bioinformatics brings the most advanced molecular modeling and simulation, bioinformatics, and computational technologies to bear on questions of biomedical relevance. It extends, refines and delivers these technologies in response to experimental progress and emerging needs of the wide biomedical research community. The impact of the work is magnified through direct collaboration with experimental researchers, the distribution of cutting-edge and user-friendly software, and via extensive training, service, and dissemination efforts. ... more
Laboratory for Fluorescence Dynamics The Laboratory for Fluorescence Dynamics (LFD is a national resource center dedicated to development of new fluorescence technologies for biology and medicine and service, training, and dissemination of fluorescence methods in a user facility. In previous years (1986-2010), we established our reputation as the leaders in technological development for fluorescence dynamics. Since moving to UCI in 2006, we expanded the core research and collaborative work in this new fertile biomedical research environment. Projects include: new ... more
Life Science and Biomedical Technology Research Resource The project will develop a world-leading suite of experimental facilities for the life-science research community. With the focus on macromolecular crystallography (MX) and x-ray scattering, there will also be user programs in correlated MX and optical spectroscopy, and one in fluorescence imaging of metals in biological materials. The extraordinary brightness of NSLS-II will provide unprecedentedly small, bright, and well-collimated x-ray beams. To exploit these qualities, extra care will be exerted to provide the best quality ... more
Macromolecular Diffraction at CHESS (MacCHESS) To understand how macromolecules such as proteins and DNA work, we need to know their structure. The "gold standard" for determining macromolecular structures at the atomic level is x-ray crystallography, and the premier source of x-rays is synchrotron radiation from a storage ring. The MacCHESS Research Resource supports structural biologists who use the Cornell High Energy Synchrotron Source (CHESS) to determine crystal structures of a broad range of biomedically relevant proteins and macromolecular complexes. MacCHESS ... more
National Biomedical Center for Advanced ESR Technology The National Biomedical Center for Advanced ESR Technology (ACERT) develops methods, both experimental and theoretical, of modern Electron-Spin Resonance (ESR) for biomedical applications. The technologies upon which this Center is based are in many respects unique in the world; and they are being utilized in numerous ways. One is the development of pulse-ESR methods to determine the structure of protein complexes, which are too large for crytallography or NMR, and yet provides information at an ... more
National Biomedical Computation Resource The mission of the National Biomedical Computation Resource (NBCR) is to conduct, catalyze, and enable biomedical research by harnessing forefront computational and information technologies to solve multiscale analysis challenges in basic and translational science. During our seventeen years NBCR has successfully exploited and led new technology developments in computing to benefit the biomedical research community, and bridged the gap between emerging information technologies and NIH funded science across diverse biomedical research areas. Current efforts focus ... more
National Center for Dynamic Interactome Research The emergent properties of life require the dynamic interactions of macromolecules, the two major classes of which are proteins and nucleic acids. These interactions form macromolecular machines and dynamic liaisons that shape the cell, transmit information and control cellular behaviors, and pathogenic alterations in molecular interaction networks (interactomes) underlie disease. Our understanding and modulation of biological systems, as well as their pathologies, thus relies on the ability to elucidate and interpret these interactions and their ... more
National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Center for Multiscale Modeling of Biological Systems (MMBioS) The National Center for Multiscale Modeling of Biological Systems (MMBioS) will develop tools to advance and facilitate cutting-edge research at the interface between high performance computing technology and the life sciences. Our overarching biological goal is the predictive multi-scale modeling of the spatiotemporal organization and evolution of neurosignaling systems and events. The advances made here will impact the research activities of a broad group of scientists, from molecular and structural biologists to cell and systems ... more
National Magnetic Resonance Facility at Madison The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource for biomolecular nuclear magnetic resonance (NMR) spectroscopy. NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high throughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, including complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and ... more
National Resource for Automated Molecular Microscopy The National Resource for Automated Molecular Microscopy (NRAMM) was established in 2003 with the mission of developing, testing and applying technology aimed at automating the processes involved in solving macromolecular structures using cryo-electron microscopy (cryoEM). The last decade has witnessed several dramatic milestones in the progress of Molecular Microscopy, a set of techniques and approaches used to analyze the structure of macromolecular machines using transmission electron microscopy (TEM). In 2008, maps of single macromolecules were ... more
NE-CAT Center for Macromolecular Crystallography The NE-CAT Center for Macromolecular Crystallography is a facility that uses high intensity X-rays to determine the three-dimensional arrangement of atoms in biological molecules. The Resource is located at Sector 24 of the Advanced Photon Source (APS) at Argonne National Laboratory (ANL), and overseen by the Northeastern Collaborative Access Team, which includes scientists from across the country. Determining the composition of molecules and visualizing their interactions at the molecular level provides insights into how cells transmit signals, ... more
Resource for Biocomputing, Visualization, and Informatics The Resource for Biocomputing, Visualization, and Informatics (RBVI) develops software and Web-based resources for the visualization and analysis of molecular structures and related data. Given the ever-expanding and increasingly heterogeneous universe of information on biological molecules - structural data at scales ranging from atomic to supramolecular, sequences, expression data, physical and genetic interactions, functional roles, associations with disease - researchers require truly integrative software to promote understanding of the data as a coherent whole. The ... more
Resource for Integrated Glycotechnology The central goal of the Research Resource for Integrated Glycotechnology is to increase understanding of the molecular basis of protein-carbohydrate interactions in disease and to develop more powerful technologies necessary to achieve this understanding. The carbohydrates (glycans) found on cell surfaces and circulating as parts of soluble glycoproteins play a role in many biomedically important processes, including inflammatory response, hormone action, malignancy, viral and bacterial infections and cell differentiation. Over the past few years the ... more
Synchrotron Radiation Structural Biology Resource The SSRL Structural Molecular Biology (SMB) program operates as an integrated resource and has three primary areas (or cores) of technological research and development and scientific focus: macromolecular crystallography (MC), x-ray absorption spectroscopy (XAS), and small angle x-ray scattering/diffraction (SAXS).Central to the core technological developments in all three of these areas is the development and utilization of improved detectors and instrumentation, especially to be able to take maximum advantage of the increasingly high brightness of ... more
Ultrafast Optical Processes Laboratory The Regional Laser and Biomedical Technology Laboratories (RLBL) at the University of Pennsylvania, specializes in the application of laser spectroscopy to biochemical, biophysical and biomedical research. The primary focus is on developing laser-based technologies to measure atomic level features of the fastest steps occurring in biological processes. This involves a balanced approach concerned with the design and implementation of laser systems, the incorporation of advances in laser technology into configurations suitable for biophysical research and ... more
Yeast Resource Center The Yeast Resource Center (YRC) is a NCRR and NIGMS Biomedical Technology Research Center based at the University of Washington in Seattle, Washington. The YRC's mission is to (1) exploit the budding yeast Saccharomyces cerevisiae to develop novel technologies for investigating and characterizing protein function and protein structure (2) facilitate research and extension of new technologies through collaboration, and (3) actively disseminate data and technology to the research community. Through collaboration, the YRC freely provides ... more
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Biophysics Collaborative Access Team The Biophysics Collaborative Access Team (BioCAT) operates undulator beamline 18ID at the Advanced Photon Source, Argonne National Laboratory. BioCAT's mission is to provide a national research resource for using X-ray diffraction, scattering and spectroscopic imaging technologies for the study of partially ordered biological molecules, complexes of biomolecules, and cellular structures under conditions similar to those present in living cells and tissues. The goal of this research is to understand the detailed mechanisms of action of ... more
Life Science and Biomedical Technology Research Resource The project will develop a world-leading suite of experimental facilities for the life-science research community. With the focus on macromolecular crystallography (MX) and x-ray scattering, there will also be user programs in correlated MX and optical spectroscopy, and one in fluorescence imaging of metals in biological materials. The extraordinary brightness of NSLS-II will provide unprecedentedly small, bright, and well-collimated x-ray beams. To exploit these qualities, extra care will be exerted to provide the best quality ... more
Macromolecular Diffraction at CHESS (MacCHESS) To understand how macromolecules such as proteins and DNA work, we need to know their structure. The "gold standard" for determining macromolecular structures at the atomic level is x-ray crystallography, and the premier source of x-rays is synchrotron radiation from a storage ring. The MacCHESS Research Resource supports structural biologists who use the Cornell High Energy Synchrotron Source (CHESS) to determine crystal structures of a broad range of biomedically relevant proteins and macromolecular complexes. MacCHESS ... more
National Center for X-Ray Tomography The National Center for X-ray Tomography develops novel cellular imaging technologies for biological and biomedical research. In particular, the NCXT is developing soft x-ray tomography as a new tool for visualizing and quantifying the internal structure of whole, hydrated cells, and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules. Data from these two imaging modalities can be combined to form a single, correlated imaging view of a cell. This work is ... more
NE-CAT Center for Macromolecular Crystallography The NE-CAT Center for Macromolecular Crystallography is a facility that uses high intensity X-rays to determine the three-dimensional arrangement of atoms in biological molecules. The Resource is located at Sector 24 of the Advanced Photon Source (APS) at Argonne National Laboratory (ANL), and overseen by the Northeastern Collaborative Access Team, which includes scientists from across the country. Determining the composition of molecules and visualizing their interactions at the molecular level provides insights into how cells transmit signals, ... more
Synchrotron Radiation Structural Biology Resource The SSRL Structural Molecular Biology (SMB) program operates as an integrated resource and has three primary areas (or cores) of technological research and development and scientific focus: macromolecular crystallography (MC), x-ray absorption spectroscopy (XAS), and small angle x-ray scattering/diffraction (SAXS).Central to the core technological developments in all three of these areas is the development and utilization of improved detectors and instrumentation, especially to be able to take maximum advantage of the increasingly high brightness of ... more
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National Center for Macromolecular Imaging Protein molecules and macromolecular assemblies perform the vast majority of chemical and physical actions within the cell. These tiny molecular machines perform extremely complex actions, and yet are only 10-100 nm in size. This is too small to be seen using the best possible light microscope, as they are smaller than the wavelength of visible light. In transmission electron microscopy (TEM), imaging is performed using electrons, with wavelengths of less than 0.001 nm. While the ... more
National Center for Microscopy and Imaging Research The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer-aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, a range encompassing macromolecules, subcellular structures and cells. With novel specimen staining methods, imaging instruments and computational capabilities, researchers are addressing the next great biological challenges in the post-genomic age by situating proteins and macromolecular complexes in their cellular and tissue environments. ... more
National Center for X-Ray Tomography The National Center for X-ray Tomography develops novel cellular imaging technologies for biological and biomedical research. In particular, the NCXT is developing soft x-ray tomography as a new tool for visualizing and quantifying the internal structure of whole, hydrated cells, and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules. Data from these two imaging modalities can be combined to form a single, correlated imaging view of a cell. This work is ... more
The Boulder Laboratory for 3-D Electron Microscopy of Cells The Boulder laboratory for 3-D electron microscopy of cells has functioned as a NCRR funded research resource since 1970. The lab has been successful in developing methods for imaging diverse cells and tissues in three dimensions (3-D) at a resolution of ~ 5 nm. The numerous features of cell structure that become visible at this level are highly informative about the mechanisms that underlie cellular processes. The overall strategy of the current research in the ... more
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BioCurrents Research Center This center offers a suite of advanced technologies designed to follow the dynamic properties of living cells, particularly as these relate to molecular transport and pathophysiology. Developed in-house are several electrochemical noninvasive microelectrode applications (<10µm tip diameters) relying on drift and noise reduction by using a modulation technique, termed self-referencing. Using differential signal analysis, the center offers techniques that can measure chemical gradients surrounding single cells and tissues. Applications using potentiometry, voltammetry, and amperometry are ... more
Human Genetic Analysis Resource Research Emphasis The Human Genetic Analysis Resource (H.G.A.R.) is developing a user-friendly software package, S.A.G.E. (Statistical Analysis for Genetic Epidemiology), that can be used to analyze family data to determine whether the variability of a trait, either quantitative or qualitative, is significantly due to Mendelian segregation at a single genetic locus; whether there is an association between a quantitative or qualitative trait and a known polymorphic genetic marker; and whether there are genetic loci linked ... more
Macromolecular Crystallography at the National Synchrotron Light Source The Macromolecular Crystallography Research Resource (PXRR) provides facilities and support at the National Synchrotron Light Source for the benefit of outside and in-house investigators. The PXRR is supported by the NIH's National Center for Research Resources, and by the DOE Office of Biological and Environmental Research in its mission to create optimal facilities and environments for macromolecular structure determination by synchrotron X-ray diffraction. With a staff of about 18, the PXRR innovates new access modes ... more
Multiscale Modeling Tools for Structural Biology The Center for Multiscale Modeling Tools for Structural Biology (MMTSB) develops and applies new modeling tools and methods that interface with problems in structural and functional biology. There is an increasingly vital need for structurally-based mechanical models of biomolecular assemblies, e.g., viruses, the ribosome, molecular motors and machines, in order to interpret and inform experiments coming from structure based methods such as X-yray diffraction and cryo-EM as well as single molecule methods such as optical ... more
National Center for Glycomics and Glycoproteomic The National Center for Glycomics and Glycoproteomics (NCGG) focuses on developing highly sensitive methodologies and new instrumental capabilities for glycomic and glycoproteomic analyses of complex biological systems. In collaboration with biological and biomedical investigators, conceptually important applications are being sought to emphasize the advantages of sensitive and accurate measurements as well as the structural information provided through bioinformatic tools in glycomics and glycoproteomics. The unique methodologies offered by the center include isotopically-coded glycan analysis by ... more
National Flow Cytometry and Sorting Research Resource The resource advances flow cytometric analyses through innovative research, development, and collaborations. Flow cytometry is a technique for high-speed analysis of individual particles ranging in size from single molecules and macromolecular complexes to subcellular organelles, cells, and cellular aggregates. Particles pass rapidly through one or more focused laser beams, where probe molecules bound to specific components, such as DNA in cells, are excited and the emitted fluorescence photons are detected. Measurement of fluorescence emissions and ... more
National Resource for Biomedical Supercomputing The National Resource for Biomedical Supercomputing (NRBSC) pursues leading edge research in the life sciences utilizing high performance computing, and fosters exchange between expertise in computational science at the Pittsburgh Supercomputing Center and biomedical researchers nationwide. NRBSC's focus is two-fold: computational biomedical research and outreach to the national biomedical research community through education and publications. Research at NRBSC is centered in three areas: cell modeling with a focus on investigating neural function; large scale volumetric ... more
Visualization of Biological Complexity Resource The resource develops methods for the three-dimensional (3-D) visualization of biological systems over a wide range of scales, from macromolecular assemblies to cells, using electron microscopy and advanced computational methods. Driven by research projects studying the mitochondrion, kinetochore, calcium release channel, and ribosome, the following three areas of technology and research development are pursued. Cryoelectron tomography: This center is working to improve tomographic resolution for identification of macromolecular complexes in cells and to extend cryotomographic ... more

 


P41 Centers with NIBIB

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Integrated Technologies for Polymeric Biomaterials, RESBIO The Resource Integrated Technologies for Polymeric Biomaterials (RESBIO) works to develop integrated tools and technologies that advance the discovery of polymeric biomaterials for regenerative medicine, the delivery of biological agents, and the next generation of medical implants. To achieve its mission, RESBIO's research is focused on the development of combinatorial and computational approaches to biomaterials design and optimization. Within this framework, RESBIO employs and uses: Advanced multi-photon confocal laser microscopy to explore, understand, and control ... more
Surface Analysis Facility for Biomedical Problems The National ESCA and Surface Analysis Center for Biomedical Problems (NESAC/BIO) provides state-of-the-art surface analysis expertise, instrumentation, experimental protocols, and data analysis methods to address surface-related biomedical problems. NESAC/BIO develops and applies surface science methodologies that produce a full understanding of the surface composition, structure, spatial distribution, and orientation of biomaterials and adsorbed biomolecules. The NESAC/BIO program identifies areas where surface science must evolve to keep pace with the growth in biochemical knowledge and biomaterial ... more
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Laboratory of Neuro Imaging Resource The Laboratory of Neuro Imaging Resource (LONIR) develops novel strategies to investigate brain structure and function in their full multidimensional complexity. There is a rapidly growing need for brain models comprehensive enough to represent brain structure and function as they change across time in large populations, in different disease states, across imaging modalities, across age and sex, and even across species. International networks of collaborators are provided with a diverse array of tools to create, ... more
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Neuroimaging Analysis Center The Neuroimage Analysis Center (NAC) is an NIH-sponsored National Resource Center dedicated to the development of imaging, algorithms, and software tools that improve our understanding of brain diseases and enable innovative treatments. The center is organized around four research cores. The White Matter Architecture from Diffusion Tensor Images Core focuses on algorithms to elucidate and quantify white matter in individuals and populations. The fMRI Informatics Core extracts information on brain function by developing statistical technologies ... more
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National Resource Center for Image-Guided Therapy The National Center for Image Guided Therapy (NCIGT), an NIH funded Biomedical Technology Resource Center, serves as a national resource for all aspects of research into medical procedures that are enhanced by imaging. Its common goal is to provide more effective patient care. The center is focused on the multidisciplinary development of innovative image-guided intervention technologies to enable effective, less invasive clinical treatments that are not only more economical, but also produce better results for ... more
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Center for Advanced Imaging Innovation and Research (CAI2R) The Center for Advanced Imaging Innovation and Research (CAI2R) develops novel imaging technologies for the improved management of cancer, musculoskeletal disease, and neurological disease, employing a unique new model for interdepartmental and academic-industrial collaboration to translate those technologies rapidly into clinical practice. By exploiting connections between imaging modalities such as MRI and PET, we aim to advance the fundamental capabilities of each, so as to expand biomedical knowledge and improve the care of patients. CAI2R ... more
Center for Advanced Magnetic Resonance Technology at Stanford The Center for Advanced Magnetic Resonance Technology develops innovative technologies in five core research areas of magnetic resonance imaging and spectroscopy (MRI/MRS): image reconstruction, fast imaging and radiofrequency (RF) pulse design methods, R hardware development, body imaging methods, neuroimaging methods, and (5) MR spectroscopy methods. In each of these areas, we capitalize on the long-standing, successful partnership and extensive experience in Stanford's Radiology and Electrical Engineering departments to improve and expand imaging technology for use ... more
Center for Electron Paramagnetic Resonance Imaging in Vivo Physiology The major aim of this resource is the development of instrumentation, including novel resonant structures , analysis techniques, spin probes, and methodologies for imaging physiologically relevant aspects of tissue fluids, including high-resolution quantitative molecular oxygen (pO2) images, with very low frequency electron paramagnetic resonance imaging (EPRI). Novel bridges and high-access, magnet/gradient systems have produced physiologically relevant images of the oxygen dependence of the response of malignant tumors to conventional therapy (radiation) and the interaction between molecular biologic characteristics of tumor cells ... more
Center for Functional Imaging Technologies The Center for Functional Neuroimaging Technologies is a Regional Resource located at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital. Working within the integrated multimodal imaging environment of the Martinos Center, the goal of the Resource is to develop and apply innovative neuroimaging technologies and techniques to enable closer examination of the human brain, and thereby contribute to better understanding of the brain in health and disease. To this end, ... more
Center for Magnetic Resonance and Optical Imaging The primary goal of the Center for Magnetic Resonance and Optical Imaging (CMROI) is to develop state-of-the-art core Magnetic Resonance and Optical biomedical imaging technologies for solving important problems in biomedical research with a special emphasis on the rapid clinical translation. These technological developments are driven by collaboration with scientists from within and outside University of Pennsylvania, the primary institution. Specifically, the Resource is focused on the development of quantitative, noninvasive MR and optical imaging ... more
Hyperpolarized MRI Technology Resource Center Hyperpolarized MRI using Dynamic Nuclear Polarization (DNP) is a powerful new imaging technique which uses specialized instrumentation to provide signal enhancements of over 5-orders of magnitude for carbon-13 enriched compounds. The resulting hyperpolarized solution then can be injected in a MR scanner to detect rapidly not only the uptake of the targeted molecule but also its metabolic products in vivo using rapid 13C MR acquisitions. Through the initial HP MR studies, it has become clear ... more
Integrated Center for In Vivo Microscopy The goal of the Duke Center for in Vivo Microscopy (CIVM) is to develop novel preclinical imaging tools and make these methods widely available to collaborators in the basic sciences for comprehensive insight into major diseases. We develop multimodality protocols that integrate the best of different imaging technologies. CIVM has played a major role in developing and enhancing MR microscopy, as well as developing MR with hyperpolarized gases like 3He and 129Xe, now moving into ... more
Laboratory of Neuro Imaging Resource The Laboratory of Neuro Imaging Resource (LONIR) develops novel strategies to investigate brain structure and function in their full multidimensional complexity. There is a rapidly growing need for brain models comprehensive enough to represent brain structure and function as they change across time in large populations, in different disease states, across imaging modalities, across age and sex, and even across species. International networks of collaborators are provided with a diverse array of tools to create, ... more
MIT-Harvard Center for Magnetic Resonance In brief, the objectives of CMR are: to develop sophisticated technologies for magnetic resonance in the areas of solution-state NMR, solid-state NMR, electron paramagnetic resonance (EPR), and dynamic nuclear polarization (DNP); to apply those technologies to biologically and medically significant research, both in-house and collaboratively; to operate a state-of-the-art instrument facility to serve needs of researchers in chemistry, biology, and medicine; and to openly disseminate and provide training in technological developments at the Center. In ... more
National Biomedical EPR Center Development of multiquantum Q- and W-band spectrometers, including multiquantum ELDOR, development of time-locked sub-sampling (TLSS) for broadband detection of periodically modulated signalsDevelopment of loop-gap resonators using finite element modeling of Maxwell's equationsApplication of multifrequency (1 to 100 GHz) electron paramagnetic resonance (EPR) to characterize paramagnetic centersStudy of relaxation processes using multifrequency pulse saturation recoveryUse of nitroxide radical spin labels to measure translational and rotational diffusion in biological systems, site-directed spin labeling (SDSL), and use of ... more
NMR Imaging and Localized Spectroscopy The Center for Magnetic Resonance Research (CMRR) focuses on development of unique magnetic resonance (MR) imaging and spectroscopy methodologies and instrumentation for the acquisition of structural, functional, and biochemical information non-invasively in humans, and utilizing this capability to investigate organ function in health and disease. The distinctive feature of this resource is the emphasis on ultrahigh magnetic fields (7 Tesla and above), which was pioneered by this BTRC. This emphasis is based on the premise ... more
Resource for NMR Molecular Imaging of Proteins The Resource is focused on the development of NMR spectroscopy for structure determination of proteins in biological supramolecular assemblies. The principal applications are to membrane-associated proteins; however, the approach is generally applicable to polypeptides that cannot be prepared in forms suitable for X-ray crystallography or multidimensional solution NMR spectroscopy. As a result, there are also applications to viruses and other biological systems.The principal instrumentation consists of high-field NMR spectrometers dedicated to high-resolution solid-state NMR spectroscopy. ... more
Resource for Quantitative Functional MRI This Resource is an interdepartmental and interdisciplinary laboratory combining facilities of the F.M. Kirby Research Center for Functional Brain Imaging at the Hugo Moser Research Institute at Kennedy Krieger (KKI) and the Center for Imaging Science (CIS) at Johns Hopkins University (JHU). It provides expertise for the design of quantitative magnetic resonance imaging (MRI) and spectroscopy (MRS) data acquisition and processing technologies that facilitate the biomedical research of a large community of clinicians and neuroscientists ... more
Southwestern NMR Center for In Vivo Metabolism The Southwestern NMR Center for In Vivo Metabolism exists to develop and apply new methods for analysis of metabolic networks in intact tissues, animals and human patients. The importance of understanding abnormal metabolism in common diseases such as cancer, diabetes and heart disease has long been appreciated. Because of constraints in technology, however, much of this research has been conducted in isolated systems where clinical relevance may be uncertain. Advances in magnetic resonance technology provide ... more
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Biomedical Simulations Resource (BMSR) The Biomedical Simulations Resource (BMSR) in the Department of Biomedical Engineering at the University of Southern California is dedicated to the advancement of the state-of-the-art in biomedical modeling and simulation through Core and Collaborative Research projects, as well as the dissemination of this knowledge and related software through Service, Training and Dissemination activities aimed at the biomedical community at large. The BMSR includes four core research projects: Pharmacokinetic/Pharmacodynamic Systems Analysis - David Z. D'Argenio, Ph.D., ... more
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Computer Integrated Systems for Microscopy and Manipulation The goal of CISMM is to develop force technologies applicable over a wide range of biological settings, from the single molecule to the tissue, with integrated systems that orchestrate facile instrument control, multimodal imaging, and analysis through visualization and modeling.Our Force Microscope Technologies Core designs instruments in an area of science where there are unusual opportunities: the measurement of forces and the integration with optical microscopy. Force technologies play the obvious role of both measuring ... more
National Center for Adaptive Neurotechnologies This BTRC creates software, hardware, and protocols that support complex real-time interactions with the central nervous system (CNS). It is founded on two major advances, one scientific and one technological. The scientific advance is the recognition that activity-dependent plasticity occurs continually throughout the CNS and throughout life; this plasticity is driven and shaped by the ongoing interactions between the CNS and the world. The technological advance is the development and availability of hardware and software ... more
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Center for Gamma-Ray Imaging The primary focus of the Center for Gamma-Ray Imaging (CGRI) is to develop new gamma-ray imaging instruments and techniques that yield substantially improved spatial and temporal resolutions. The Center makes its imagers and expertise available to a wide community of biomedical and clinical researchers through collaborative and service-oriented interactions. The collaborative research applies these new imaging tools to basic research in functional genomics, proteomics, cancer, cardiovascular disease and cognitive neuroscience, and to clinical research in ... more
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Center for Biomedical OCT Research and Translation The Center for Biomedical OCT Research and Translation (CBORT) pioneers and provides access to microscopic imaging instruments for biologic and clinical research. Optical coherence tomography (OCT) has evolved over the last two decades to become a standard of care for diagnostic ophthalmic imaging and is poised to make significant impact in the fields of cardiology and gastrointestinal endoscopy. Access to state-of-the-art instrumentation, however, has been limited to a relatively few research laboratories and the optimization ... more
Laser Biomedical Research Center The MIT Laser Biomedical Research Center (LBRC) develops the basic scientific understanding and new techniques required for advancing the clinical applications of lasers and spectroscopy. To fulfill the significant and ever growing need for a more comprehensive and potentially non-invasive understanding of the human body, the LBRC merges optical spectroscopy, imaging, scattering, and interferometry techniques. Specifically, researchers at the LBRC study the biophysics and biochemistry of healthy and diseased biological structures from the subcellular to ... more
Laser Microbeam and Medical Program The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in biology and medicine. LAMMP is located within the Beckman Laser Institute, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. The overall objective is to promote a well-balanced BTRC with activities in technological research and development, collaborative research, service, training, and dissemination. One of the primary goals of LAMMP is to facilitate "translational" ... more
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Bio-MicroElectroMechanical Systems (BioMEMS) Resource Center The BioMEMS Resource Center's mission is to provide biomedical investigators with novel microsystems engineering tools for biological discovery, diagnostic, prognostic, and therapeutic applications. Thrust areas of interest for the BioMEMS Resource Center are the development of novel living cell-based, lab-on-a-chip type devices for sorting blood cells, for high-throughput biochemistry in small volumes, and for studying cellular behavior in controlled microenvironments.
Tissue Engineering Resource Center The Center is designed to advance the fundamental basis and clinical aspects of tissue engineering, to provide training for investigators and dissemination of scientific findings and new techniques. The expertise and facilities are focused on research, problem solving and training for the biomedical community through an integrated systems approach to the challenges in tissue engineering. A Service Core will enable and facilitate the implementation of solutions that would be impossible to attain from a single ... more
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A Resource on Medical Ultrasonic Transducer Technology The focus of this resource is to develop very high frequency (above 20 MHz) ultrasonic transducers/arrays for applications in medicine and biology that include ophthalmology, dermatology, vascular surgery, and small animal imaging. The research is pursued simultaneously in three directions: novel piezoelectric materials, very high frequency single element transducers and linear arrays, and finite element modeling and material property measurements.
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Radiological Research Accelerator Facility (RARAF) The Columbia University Radiological Research Accelerator Facility (RARAF) is a dedicated facility for radiobiological research with available ionizing radiations such as protons, alpha particles, and neutrons. RARAF is well-established and highly user-friendly. The focus of RARAF is the development of high-throughput single-cell/single-particle microbeams, which can deliver defined amounts of ionizing radiation into individual cells with a spatial resolution of a few microns or better. The ability of a microbeam to put double strand break damage ... more
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A Multidisciplinary NMR Center for Biomedical Research The focus of this resource is on developing methodologies for the acquisition of morphological, biochemical, cellular, and functional information in living animals using nuclear magnetic resonance imaging (MRI) and spectroscopy (MRS). Novel techniques utilizing multidimensional MR imaging, magnetic resonance microscopy (MRM), and multinuclear in vivo spectroscopy are being applied to a wide range of problems in the biomedical sciences.
National Resource for Imaging Mass Spectrometry The focus of this resource is the application to biomedical research of a new generation of secondary ion mass spectrometer (SIMS), the Multi-Isotope Imaging Mass Spectrometer (MIMS). MIMS is an ion microscope and an ion counter. MIMS provides high mass separation at high transmission (M / ΔM > 10,000), high spatial resolution (< 40 nm) and has the unique capability of simultaneously recording several atomic mass images. Of the utmost importance, MIMS makes it possible ... more
Resource for MRI of Neurodegenerative Disorders The Center for Imaging of Neurodegenerative Diseases (CIND) develops and validates new imaging methods for detecting brain abnormalities in neurodegenerative diseases, including Alzheimer's disease, vascular dementia, frontotemporal dementia, Parkinson's disease, as well as epilepsy, depression, and other conditions associated with nerve loss in the brain. As people around the globe live longer, the impact of neurodegenerative diseases is expected to increase further with dire social and economical consequences for societies if no effective treatments are ... more